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The International Dry Eye Workshop1 defines dry eye syndrome (DES) as a multifactorial heterogeneous disease of the tear film and ocular surface that results in discomfort, visual acuity disturbance and tear film instability. It arises when there is disruption to the lid surface and function, cornea sensation, blink reflex, tear film production and stability, tear composition and drainage2, 3 leading to complications such as persistent corneal epitheliopathy and corneal infection. DES affects nearly 3.23 million women, 1.68 million men and 4.91 million Americans 50 years and older4.

A wide range of treatment options is available in the management of DES, including topical lubricants or artificial tear substitutes, ointments or gels, topical secretagogues, anti-inflammatory therapy, biologic tear substitutes, punctal occlusion, moisture chamber goggles and surgery. Artificial tears arguably provide the most affordable, immediate and least invasive form of relief. Previous generations include integrated natural polymers (such as cellulose derivatives) and synthetic polymers [(such as polyvinyl alcohol (PVA) and hydroxypropylguar (HP Guar)].

In recent decades, sodium hyaluronate has emerged as an option in artificial tear therapy. It owes its efficacy to hyaluronic acid (HY), a naturally occurring linear biopolymer consisting of repeating disaccharide units of N-acetyl-D-glucosamine and sodium-D-glucoronate. HY is widely used today and has been shown to result in both subjective and objective improvement of DES. A recent meta-analysis by Kong X. et al.5 compared the effect of HY and non-HY preparations in symptomatic relief of subjects and could not demonstrate superiority of one preparation over the other. However, the comparative efficacy of both artificial tears with regard to all other common outcome measures of DES remains unclear.

Are there any food restrictions
Avoid Alcohol

How do I store Clarithromycin :
Intravenous: Store at 15-25°C. Store the tablets at room temperature and away from excess heat and moisture. Do not refrigerate the oral solution.

Pregnancy Category
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification
Macrolides