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The interactions of drugs with people who take them—how the compounds are absorbed, metabolized, distributed, and excreted—is referred to as pharmacokinetics. Antimalarial drugs differ considerably in their pharmacokinetics, which affect how well they work, how they are dosed, and how long they must be taken. People also vary in how they respond to drugs. Some of these responses are genetically determined, others by
health status, others by dietary factors. In general, the pharmacokinetic properties of the antimalarials are similar in children
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